Oral fluoroquinolone prophylaxis during salvage chemotherapy for relapsed/refractory lymphoma is controversial. In this study, we retrospectively evaluated the effect of prophylactic levofloxacin (LVFX) in patients with relapsed/refractory lymphoma who underwent salvage chemotherapy during a recent 11-year period at our hospital. Forty-five patients and 111 cyclesof chemotherapy were included in this study. The prophylaxis of LVFX was conducted in 59 cycles (53.2%). The proportion of female patients, relative dose intensity < 1.0, and absolute neutrophil count ≥ 1,500/μL were significantly higher in lymphoma patients without LVFX prophylaxis than in those with LVFX prophylaxis ( p < 0.05). Most patients in these groups received the prophylactic use of Granulocyte Colony Stimulating Factor. The incidence rate of febrile neutropenia (FN) was 51.9% (27 cycles) in the group without prophylaxis and 49.1% (29 cycles) in the LVFX prophylaxis group. The median duration of hospitalization was 22.42 ± 1.39 days in the group without prophylaxis group and 23. 07 ± 1. 28 days in the group with prophylaxis. There were no statistically significant differences between these groups. Prophylactic LVFX did not contribute to reducing the risk of FN and shortening the hospitalization duration in our patients with relapsed/refractory lymphoma who were receiving salvage chemotherapy.

[Introduction]The Yuai-Kai Foundation and Oda Hospital provide 24-hour care for patients with dementia in a specialized unit, the Dementia Care Unit (DCU). This pilot study aimed to examine in an acute care setting changes in activities of daily living and behavioral and psychological symptoms of dementia in inpatients with dementia who were admitted to the DCU.
[Methods]This study included patients aged 75 years or older with a Cognitive Function Score (CFS) of IIIa or higher, who were admitted to the DCU at Oda Hospital between April 1 and October 14, 2020. Univariate analysis was performed to compare Bedriddenness Ranks, CFS, Barthel index, Mini-Mental State Examination, and ABC dementia scale (ABC-DS) at both admission and discharge from the DCU.
[Results]During the study period, 43 patients were admitted to DCU. Between admission and discharge from the DCU, Bedriddenness Ranks and CFS showed significant changes. The score for domain B of ABC–DS significantly improved from 23 to 25 points.
[Conclusions]Interventions in a DCU can effectively improve behavioral and psychological symptoms of dementia in inpatients of acute care hospitals.